Buku Zoologi Vertebrata.pdf
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pH-Induced alterations in equine monocyte-macrophages.
Monocytes/macrophages are the first line of defense against invading pathogens and are also important in innate and adaptive immune responses. Studies examining responses of human monocyte-macrophages to environmental signals and alterations in their phenotype have been well documented. However, little is known about the responses of equine monocyte-macrophages. We examined alterations in equine monocyte-macrophage responses after acidification. Equine monocytes were incubated at a constant pH of 6.0, 7.0 or 8.0 for 1 h before being subjected to a panel of macrophage activators to determine their response to these stimuli. We found that equine monocytes/macrophages are more potent inducers of IL-1beta in response to 1-methyl-2-acetamido-3-butylimidazolium (P “PewDiePie’s current fans is significantly